Topographical Distribution of Cerebral Cortical Thinning in Patients with Mild Parkinson's Disease Without Dementia
Identifieur interne : 001F05 ( Main/Exploration ); précédent : 001F04; suivant : 001F06Topographical Distribution of Cerebral Cortical Thinning in Patients with Mild Parkinson's Disease Without Dementia
Auteurs : CHUL HYOUNG LYOO [Corée du Sud] ; YOUNG HOON RYU [Corée du Sud] ; MYUNG SIK LEE [Corée du Sud]Source :
- Movement disorders [ 0885-3185 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
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Abstract
The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD.
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aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0178223</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0178223 INIST</idno><idno type="RBID">Pascal:10-0178223</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C07</idno><idno type="wicri:Area/PascalFrancis/Curation">002112</idno><idno 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sortKey="Young Hoon Ryu" sort="Young Hoon Ryu" uniqKey="Young Hoon Ryu" last="Young Hoon Ryu">YOUNG HOON RYU</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>2 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine</s1><s2>Seoul</s2><s3>KOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Corée du Sud</country><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dementia</term><term>Encephalon</term><term>Human</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Démence</term><term>Pathologie du système nerveux</term><term>Encéphale</term><term>Homme</term><term>Imagerie RMN</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathology of Parkinson's disease (PD) is not confined to the brainstem regions, but spreads to involve the neocortical areas. Using surface-based cortical thickness analysis, we studied the topographical distribution of cortical thinning in nondemented patients with mild PD. The high-resolution magnetic resonance imaging (MRI) studies were performed in 48 patients with PD without dementia and 56 age-matched healthy controls. Using the Freesurfer software, surface-based analysis was done to find changes in cerebral cortical thickness in patients with PD. Compared to the controls, patients with PD showed significant cortical thinning in the temporal, inferior parietal, rostral frontal, and orbitofrontal cortical areas. Thinning of the cerebral cortex occurs even in nondemented patients with mild PD, and its topographical distribution was similar to that of the neocortical Lewy bodies. Further studies are needed to find pathological and clinical correlates of thinned cerebral cortex found in nondemented patients with mild PD.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Chul Hyoung Lyoo" sort="Chul Hyoung Lyoo" uniqKey="Chul Hyoung Lyoo" last="Chul Hyoung Lyoo">CHUL HYOUNG LYOO</name></noRegion><name sortKey="Myung Sik Lee" sort="Myung Sik Lee" uniqKey="Myung Sik Lee" last="Myung Sik Lee">MYUNG SIK LEE</name><name sortKey="Young Hoon Ryu" sort="Young Hoon Ryu" uniqKey="Young Hoon Ryu" last="Young Hoon Ryu">YOUNG HOON RYU</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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